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Genomi vs Katra

Which one should you try?

Genomi

Free

Best for Genomics researchers wanting AI-powered interpretations of personal genomes

Katra

Free

Best for Developers building MCP-compatible AI agents

Pricing, capabilities and platforms side by side. Prices are as of the "Pricing checked" date in the table.

Genomi

Genomi

The core workflow is four steps: install the agent harness, point it at your raw genome file on disk, build a local SQLite index, then ask questions through whichever AI agent you already run — Claude Code, Cursor, Gemini CLI, Goose, and others are listed as compatible. Pharmacogenomics, carrier status, polygenic risk scores, nutrigenomics, and ancestry PCA projection are all covered through distinct skill modules backed by ClinVar, PharmCAT, PGS Catalog, HPO, GenCC, and 1000 Genomes reference data. The privacy architecture is explicit: raw genome data stays on disk, and only the specific evidence snippets relevant to a query cross the boundary to whatever LLM handles the response. The vendor marks this as experimental and not for clinical use — which means researchers and privacy-conscious individuals exploring personal data are the intended audience, not clinical teams expecting diagnostic-grade output.

Katra

Katra

Katra is self-hosted memory infrastructure: drop it on any Docker-capable machine, point your MCP-compatible agent at it, and you get episodic recall, semantic search, knowledge graphs, and temporal analysis without rebuilding your agent. The architecture is a single deployable unit — the vendor describes it as a 'memory appliance' — which means setup friction is low for teams that already run Docker or Helm on AWS. Where it breaks: Katra is memory infrastructure, not an agent runner, so teams expecting built-in task planning or tool execution will need to wire those themselves. The project is early-stage with five stars on GitHub and no reported production deployments in public community channels, which means you are taking on the role of early adopter rather than stepping into a proven stack.

AttributeGenomiKatra
PricingFreeFree
Pricing checkedNot checked yetNot checked yet
Free trialNot statedNot stated
Open sourceYesYes
Has APINoYes
Self-hosted optionYesYes
PlatformsLinux, macOS, Windows (Python-based)Docker
Released2024—
Pros
  • Local-first data architecture keeps the raw genome file on disk and only sends queried evidence snippets to the LLM, so teams with strict data policies can explore personal genomic data without uploading a single variant to a third-party server.
  • Skill modules cover pharmacogenomics via PharmCAT and ClinPGx, carrier status via ClinVar and HPO, polygenic risk via PGS Catalog, and ancestry via 1000 Genomes PCA — so a researcher doesn't have to stitch together five separate tools and manually reconcile their outputs.
  • Each answer carries source attribution and stated evidence limits, which means you can trace a finding back to ClinVar or GenCC rather than accepting a response with no provenance — a real gap in generic LLM genomic Q&A.
  • Agent-agnostic MCP and skills-host architecture plugs into whichever AI agent a team already runs, so there is no forced migration to a new interface or locked-in model provider.
  • Apache-2.0 open-source license with self-hosted deployment means developers building agent-based genomic analysis tools can inspect, modify, and extend the skill layer without negotiating commercial terms.
  • MCP-native protocol support, so agents that already speak MCP connect without writing a custom memory adapter — which means teams skip the integration sprint that usually delays memory features.
  • Self-hosted deployment via Docker Compose or Helm, so memory data stays inside your own infrastructure — which means teams with data residency or privacy requirements can use persistent agent memory without routing sensitive context through a third-party API.
  • Shared memory store across multiple agents, so agents running in parallel read from the same knowledge base — which means you avoid the state-sync problem where two agents contradict each other because they each only remember their own session.
  • Episodic recall, semantic search, and knowledge graphs available in a single service, so you do not need to stitch together three separate systems — which means teams experimenting with cognitive memory architectures start from a single deployable unit rather than an integration exercise.
  • Apache-2.0 open-source license with Terraform, Helm, and SDK artifacts included, so teams can audit the full stack and adapt it — which means there is no vendor lock-in risk if the project direction diverges from your needs.
Cons
  • Installation requires following a source-code setup guide and configuring an AI agent to connect to the harness — non-technical users hit a wall before they ask a single question, and there is no hosted web interface to fall back on.
  • The project is vendor-labeled experimental, which means skill coverage, reference database freshness, and edge-case handling are not production-guaranteed; teams relying on consistent outputs for any regulated or clinical-adjacent workflow will find the absence of validation documentation disqualifying and will move to a certified clinical genomics platform instead.
  • There is no hosted API, so teams building products that need to serve genomic queries to end users must provision and maintain their own infrastructure — at scale, that maintenance burden is not accounted for in the zero-cost licensing.
  • Evidence snippets sent to an external LLM during a query still cross a data boundary, even if the raw genome file stays local; teams operating under strict genomic data agreements need to verify that snippet-level transmission satisfies their compliance posture before deploying, and the tool provides no compliance documentation to support that review.
  • Katra does not run agents or execute tools — it is only a memory layer. Teams that expected a full agent runtime will need to run a separate agent framework alongside it, which means maintaining two systems from day one rather than one.
  • The project has a small public footprint (five GitHub stars at time of writing, no issues or pull requests filed publicly), which means there is no community-sourced troubleshooting record to draw on when the memory service behaves unexpectedly in production. Teams hitting edge cases file the first bug report themselves.
  • Agents that do not support MCP cannot use Katra without a custom adapter layer. Teams whose agent stack is locked to a non-MCP framework — LangGraph with a native memory backend, for example — face a non-trivial porting effort and at that point are likely to evaluate mem0 or a purpose-built LangGraph memory extension instead of adapting Katra.

Made up your mind?

Genomi

Free

Best for Genomics researchers wanting AI-powered interpretations of personal genomes

Katra

Free

Best for Developers building MCP-compatible AI agents

Specs come from each tool's own site and docs (how we test). AIDiveForge is editorially independent.